THERAPEUTIC TARGETING OF ALTERNATIVE SPLICING

Therapeutic targeting of alternative splicing

Gene transcription leads to the generation of pre-mRNA molecules which contain both coding sequences (exons) and intervening non-coding sequences (introns).The primary transcript needs further processing which involves the excision of introns and ligation of exons.This process is called RNA splicing.Nearly all primary transcripts undergo alternativ

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High courts reign supreme : the role of case law in the spanish transition towards a secular (non-denominational) state

Since 1975, Spain has undergone a period of unprecedented political changes.Inspired by a democratic model in which individual rights and freedoms are effectively protected, a legal transformation has taken place in every field of Spanish Law since Democracy.It is fascinating to verify how radical the changes in religious matters have been: Spain h

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The effects of timing and rate of marine cloud brightening aerosol injection on albedo changes during the diurnal cycle of marine stratocumulus clouds

The marine-cloud brightening geoengineering technique has been suggested as a possible means of counteracting the positive radiative forcing associated with anthropogenic atmospheric CO<sub>2</sub> increases.The focus of this study is to quantify the albedo response to aerosols injected into marine stratocumulus cloud from a point sourc

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The Significance of rS Change in the V2 Lead for Diagnosing Ventricular Tachycardia Deserves Attention: A Case Report

Abstract.Occasionally, incessant ventricular tachycardia (VT) exhibits a narrow QRS complex pattern that could be Biotin misdiagnosed as supraventricular tachycardia.In this case, a 66-year-old woman was referred to the emergency department due to the worsen hemodynamic and incessant VT manifesting as a narrow QRS complex pattern that was initially

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